CD10 (56C6)

CD10, common acute lymphoblastic leukemia antigen, is expressed in early lymphoid progenitors and normal germinal center cells.1 The staining pattern is cytoplasmic. As with BCL6, an antibody against CD10 is used to identify B cells of germinal center origin and their neoplastic counterparts, such as follicular lymphoma. It can be used in combination with other stains such as BCL6, MUM1, FOXP1, GCET, and LMO2 to identify diffuse large B cell lymphoma with germinal center signature.2 This antibody almost always labels precursor B lymphoblastic leukemia/lymphoma and Burkitt lymphoma, but much less frequently labels precursor T lymphoblastic leukemia/lymphoma.2 CD10 is expressed by a subset of T follicular helper cells, although not by normal peripheral T cells. CD10 expression has been found in angioimmunoblastic T cell lymphoma (AITL).2 The expression is highly specific for AITL because other nodal peripheral T cell lymphomas only rarely express this antigen. 2,3 CD10 expression has been reported in a variety of non-hematolymphoid tissues and their neoplastic counterparts; in particular, renal cell carcinoma, endometrial stromal sarcoma, and hepatocellular carcinoma, among other malignant tumors. 4,5 The clone 56C6 shows higher staining intensity in non-hematolymphoid than hematolymphoid neoplasms.