Androgen Receptor (EP120)

Androgen receptor (AR) signaling plays a critical role in prostate cancer cell proliferation, survival, and differentiation. In the field of dermatopathology, desmoplastic trichoepithelioma (DTE), morpheaform basal cell carcinoma (BCC) and microcystic adnexal carcinoma (MAC) are sclerosing adnexal neoplasms with overlapping histopathologic features. Using CK 20 and AR for the differential diagnosis; the CK20+AR- immunophenotype was 100% sensitive and specific in diagnosing DTE. The CK20-AR+ immunophenotype was 95.24% specific and 83.33% sensitive for BCC. The CK20-AR- immunophenotype was 83.33% sensitive and 90.91% specific for MAC. CK15, CK20 and AR were positive in 87, 53 and 67% of infundibulocystic BCC cases, respectively in one study.1 Similar findings are described by Izikson L, et al.2